Thiazole is considered as a biologically important active scaffold that possesses almost all types of biological activities. Successful introduction of ritonavir as a antiviral, cefdinir as a anti-bacterial, pramipexol as a anti-alzheimer dopamine D2-agonist, abafungin as a antifungal drug, sulfathiazole, nifurthiazole as a antimicrobial drug, febuxostat as a hyperuricemic agent, famotidine, cematidine as H2 antagonist and dasatinib as a anticancer and many more species proved potential of thiazole moiety. So far, the modifications of the thiazole ring have proven highly effective and improved potency and lesser toxicity. This diversity in the biological response profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. This review is complementary work reported on preparation of thiazole and various biological activities of thiazole and its derivatives. Data are presented for active compounds, some of which have passed the preclinical testing stage and some of which are clinically approved.
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